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CCL4 Antibody / MIP-1 beta

Basic information

Name

CCL4 Antibody / MIP-1 beta

size

0.1mg

Catalog number

R31955

Price

406 €

Details and extended information

Uniprot #

P13236

Category

Antibody

Tested applications

WB, ELISA

French translation

anticorps

Conjugation

Unconjugated

Purity

Antigen affinity

Recognised antigen

CCL4 / MIP-1 beta

Clone

Polyclonal antibody

Form

Antigen affinity purified

Clonality

Polyclonal (rabbit origin)

Host animal

Rabbit (Oryctolagus cuniculus)

Recommended dilutions

Western blot: 0.1-0.5ug/ml,ELISA : 0.1-0.5ug/ml

Concentration

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Notes

Optimal dilution of the CCL4 antibody should be determined by the researcher.

Immunogen

Amino acids 24-92 of human CCL4 were used as the immunogen for the CCL4 antibody.

Intented use

This CCL4 antibodyis to be used only for research purposes and not for diagnostics..

Properties

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Species reactivity

Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

Storage

After reconstitution, the CCL4 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.

Description

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in human is encoded by the CCL4 gene. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. It is a CC chemokine with specificity for CCR5 receptors. And it is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize CCL4. Based on functional analysis of CCL4, one or more additional beta chemokine receptors that transduce CCL4 signals must also exist. MIP-1alpha and CCL4 have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many alpha as well as beta chemokines(11, 14).