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anti-CCL4 Antibody (Center)

Basic information

Name

anti-CCL4 Antibody (Center)

size

CCL4 Antibody (Center)

Catalog number

6731-100

Price

316 €

Details and extended information

Clone:

N/A

Concentration of antibody:

N/A

Target of this antibody:

CCL4

Antibody host:

Rabbit

Form of antibody:

Liquid

Shipping conditions:

gel pack

French translation

anticorps

Isotype:

Rabbit IgG

Clonality of antibody:

Polyclonal

This antibody reacts with:

Human and mouse

This antibody has been succesfully tested for use in following methods:

Western blot, IHC

Storage information:

Shelf time: 12 months in temp.: -20 deg.C

Recommended usage:

Western blot: ~1:1000, IHC: ~1:10–1:50.

Formulation of this antibody:

100 µl of antibody in PBS with 0.09% (W/V) sodium azide

How to handle this antibody:

The antibody solution should be gently mixed before use.

Purification method:

This antibody is purified through a protein A column, followed by peptide affinity purification.

Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Immunogene sequence:

This CCL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-48 amino acids from the Central region of human CCL4.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Alternative names of antibody target:

CCL4; LAG1; MIP1B; SCYA4; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2.

Background information:

CCL4 is a member of the CC- subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation. CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.