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MIP-1 beta Recombinant Protein

Basic information

Name

MIP-1 beta Recombinant Protein

size

0.002 mg, 0.01 mg

Catalog number

40-358

Price

683 €

Details and extended information

NCBI ID

20303

Uniprot

P14097

Protein's origin

Murine

Recombinant in

E. coli

Rec. PROTEIN GI#

7305459

Vial

Lyophilized

Accession nr

NP_038680.1

Group

recombinants

Source

Mus musculus

Additional source

Recombinants or rec. proteins

Gene name

chemokine (C-C motif) ligand 4

About

This product is for research use only.

SEQUENCE

APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN

Other name of the recombinant

Act-2, Mip1b, Scya4, MIP-1B, AT744.1, C-C motif chemokine 4, Immune activation protein 2, ACT-2

Pureity

Greater than 95% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Activity

Biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 20.0 - 100.0 ng/mL.

Keep at

The lyophilized MIP-1 beta recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted MIP-1 beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing MIP-1 beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

About recombinant protein

Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.