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Recombinant Mouse C-C Motif Chemokine 9/CCL9//MIP-1-γProtein 50µg

Basic information

Name

Recombinant Mouse C-C Motif Chemokine 9/CCL9//MIP-1-γProtein 50µg

size

50µg

Catalog number

PKSM040984-50µg

Price

438 €

Details and extended information

Activity

NA

Fusion tag

NA

Accession

P51670

Expressed Host

E.coli

AP Mol Mass

15 kDa

Mol Mass

11.6 kDa

Latin name

Mus musculus

Sequence

Gln22-Gln122

Group

recombinants

Source

Recombinants or rec. proteins

Purity

>90% as determined by reducing SDS-PAGE.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl,300mM NaCl,pH8.0.

Description

Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Elabscience in 1.

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Synonym

C-C motif chemokine 9; CCF18; Macrophage inflammatory protein 1-gamma; Macrophage inflammatory protein-related protein 2; Small-inducible cytokine A9; Scya10;Scya9 and CCL9.

Stability and Storage

Lyophilized protein should be stored at <-20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at <-20℃ for 3 months

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Background

C-C motif chemokine 9(CCL9) is an 11 kDa, secreted, monomeric polypeptide that belongs to the beta (or CC) intercrine family of chemokines. It is expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain. Monokine has inflammatory, pyrogenic and chemokinetic properties. It circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor,it activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors. CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption.