Details and extended information

Analyses

Gene Name

CCL4

Raised in

rabbit

Uniprot ID

P14097

French translation

anticorps

Product form

freeze-dried

Target antigen

CCL4/MIP1 beta

Clonality

Polyclonal antibody

Clone

Polyclonal antibody

Protein Name

C-C motif chemokine 4

Type of the antibody

IgG polyclonal antibody

Purification

Immunogen affinity purified.

Gene Full Name

chemokine(C-C motif) ligand 4

Reacts with species:

human, rat Predicted to work with: mouse

Product configuration

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse CCL4 (74-88aa CANPSEPWVTEYMSD).

Solubilization

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Tips

The CCL4/MIP1 beta Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Storage condtions

Keep the CCL4/MIP1 beta Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

1. Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). Nucleic Acids Res. 18 (11): 3261–70. 2. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 1126–32. 3. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). Science (journal) 270 (5243): 1811–5. 4. Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001).

Background

Chemokine(C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. Modi et al.(1991) assigned the SCYA4 gene to a slightly more distal location than had Irving et al.(1990): 17q21-q23 rather than 17q11-q21.

Synonyms

CCL4/MIP1 beta Antibody

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