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MIP-1 alpha Recombinant Protein

Basic information

Name

MIP-1 alpha Recombinant Protein

size

0.005 mg, 0.02 mg

Catalog number

40-412

Price

683 €

Details and extended information

Protein's origin

Rat

NCBI ID

25542

Uniprot

P50229

Recombinant in

E. coli

Rec. PROTEIN GI#

40254794

Vial

Lyophilized

Accession nr

NP_037157.2

Group

recombinants

Source

Rattus norvegicus

Additional source

Recombinants or rec. proteins

Gene name

chemokine (C-C motif) ligand 3

About

This product is for research use only.

SEQUENCE

APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA

Description

The MIP-1 alpha Recombinant Protein is a α- or alpha protein sometimes glycoprotein present in blood.

Other name of the recombinant

Scya3, MIP-1a, Mip1a, Scya3, C-C motif chemokine 3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha

Pureity

Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Activity

Biological activity was determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0 - 100.0 ng/mL.

Keep at

The lyophilized MIP-1 alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted MIP-1 alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing MIP-1 alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

About recombinant protein

Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.